The early identification of Down Syndrome serves as a necessity to obtain proper medical care together with support services. Actual diagnostic systems use karyotyping along with genetic testing yet these techniques remain expensive while being intrusive and taking much time to complete. This research develops a new transfer learning-based method which diagnoses DS through facial image assessment without causing harm to patients. The VNL-Net system merges three components to perform diagnosis: it starts with spatial feature extraction through VGG16 before utilizing Non-Negative Matrix Factorization for dimensionality reduction then finishes with Light Gradient Boosting Machine for feature generation. K-fold cross-validation combined with a Logistic Regression classifier provides the system with final dataset classification capabilities through performance reliability across different datasets. The researchers created a MobileNet + SVM hybrid model as a solution for efficient diagnosis which enables operation on mobile devices and edge platforms. The facial image data for training the system comes from the publicly accessible Kaggle dataset that shows pictures of both DS-affected children along with unaffected ones. The new system demonstrates its effectiveness through extensive testing that confirms it obtains superior diagnostic performance compared to traditional machine learning algorithms. Hybrid classification and transfer learning work together to achieve better diagnosis results while requiring minimal hardware resources. This study establishes deep learning as a promising technology for medical image analytic applications which provides a cost-efficient tool for diagnosing Down Syndrome early. The proposed project seeks to enlarge the database collection and integrate explainable AI systems to enhance clinical acceptance through improved interpretability.
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